Prime Inc.
$50,000 - $80,000+OTR, Regional, Refrigerated, Tanker, Flatbed
Very High Demand
Regional Truck Driver Jobs in Missouri
Browse regional trucking positions across Missouri with top carriers hiring now.
Average Pay
$52,000 - $76,000
Demand Level
Very High
Top Carriers
5+ Hiring
Key Cities
5+ Markets
Regional Trucking in Missouri
Regional trucking from Missouri covers the industrial heartland, with routes spanning from the Great Lakes to the Plains states. The Midwest's central position means regional drivers here often get home weekly while earning competitive miles. Regional driver demand in Missouri is very high, with most positions offering weekly home time and steady freight.
Top Companies Hiring Regional Drivers in MO
View Company
Knight-Swift Transportation
$50,000 - $85,000OTR, Regional, Dedicated, Refrigerated, Intermodal
Old Dominion Freight Line
$65,000 - $100,000+Local, Regional, LTL
TForce Freight (formerly UPS Freight)
$60,000 - $90,000Local, Regional, LTL
Estes Express Lines
$58,000 - $90,000Local, Regional, LTL
Top Cities for Regional Jobs in Missouri
Columbia
Missouri
Joplin
Missouri
St. Louis
Missouri
Kansas City
Missouri
Springfield
Missouri
Key Freight Routes in Missouri
1
I-70 (Kansas City to St. Louis)
2
I-44 (Springfield to St. Louis)
3
I-35 (Kansas City north-south)
Requirements for Regional Driving in MO
- Valid CDL-A license
- 6+ months CDL-A experience (some carriers accept recent graduates)
- Clean MVR with no more than 2 moving violations in 3 years
- DOT physical card
- Willingness to travel multi-state routes within assigned region
- Pre-employment drug screen and background check
Start Your Regional Driving Career in Missouri
Submit your application and get matched with companies hiring regional drivers in MO.
Regional Trucking Jobs in Missouri — FAQs
How much do regional truck drivers make in Missouri?
Regional truck drivers in Missouri earn $52,000 - $76,000 annually, depending on experience, endorsements, and carrier. Missouri's central location and freight density help drivers maintain consistent miles, which translates to strong annual earnings. Sign-on bonuses of $3,000 to $15,000 are common at major carriers actively hiring in MO.
How often do regional drivers in Missouri get home?
Most regional driving positions based in Missouri offer weekly home time, with many carriers guaranteeing at least 34 hours off each week. Some premium regional accounts get drivers home every weekend. The frequency depends on the carrier, account, and your home terminal location relative to the regional freight lanes.
Are trucking companies in Missouri hiring regional drivers in 2026?
Yes — regional driver demand in Missouri is very high heading into 2026. Missouri is one of the top hiring markets for regional drivers, with multiple carriers offering sign-on bonuses, increased CPM rates, and accelerated hiring processes. Check individual carrier listings for current openings and application requirements in MO.