Prime Inc.
$50,000 - $80,000+OTR, Regional, Refrigerated, Tanker, Flatbed
High Demand
Over-the-Road (OTR) Jobs in Missouri
Browse otr trucking positions across Missouri with top carriers hiring now.
Average Pay
$52,000 - $81,000
Demand Level
High
Top Carriers
5+ Hiring
Key Cities
5+ Markets
OTR Trucking in Missouri
Missouri is positioned in the heart of America's freight network where major interstates intersect. OTR drivers based here can reach 80% of the U.S. population within a single driving shift, making it a prime location for long-haul carriers. Demand for OTR drivers in Missouri is high, with carriers actively recruiting experienced drivers and offering competitive sign-on bonuses. The state's strategic location keeps freight volumes consistent year-round.
Top Companies Hiring OTR Drivers in MO
View Company
Knight-Swift Transportation
$50,000 - $85,000OTR, Regional, Dedicated, Refrigerated, Intermodal
USA Truck (DB Schenker)
$50,000 - $75,000OTR, Regional, Dedicated
Roadrunner Transportation
$58,000 - $88,000OTR, Regional, LTL, Owner-Operator
CRST International
$48,000 - $80,000OTR, Regional, Dedicated, Team, Flatbed
Top Cities for OTR Jobs in Missouri
Joplin
Missouri
Columbia
Missouri
Springfield
Missouri
Kansas City
Missouri
St. Louis
Missouri
Key Freight Routes in Missouri
1
I-70 (Kansas City to St. Louis)
2
I-44 (Springfield to St. Louis)
3
I-35 (Kansas City north-south)
Requirements for OTR Driving in MO
- Valid CDL-A license
- Minimum 6 months verifiable OTR experience (some carriers accept new graduates)
- Clean MVR with no major violations in the past 3 years
- DOT physical card (medical examiner's certificate)
- Ability to pass pre-employment drug screening
- Must be at least 21 years old for interstate driving
Start Your OTR Driving Career in Missouri
Submit your application and get matched with companies hiring otr drivers in MO.
OTR Trucking Jobs in Missouri — FAQs
How much do otr truck drivers make in Missouri?
OTR truck drivers in Missouri earn $52,000 - $81,000 annually, depending on experience, endorsements, and carrier. Missouri's central location and freight density help drivers maintain consistent miles, which translates to strong annual earnings. Sign-on bonuses of $3,000 to $15,000 are common at major carriers actively hiring in MO.
What are the best OTR trucking routes through Missouri?
Missouri's interstate system connects drivers to major freight lanes across the region. Outbound loads from Missouri typically move to distribution hubs in neighboring states, while inbound freight includes consumer goods, raw materials, and manufacturing inputs. Carriers based in or running through MO offer consistent miles with multiple routing options.
Are trucking companies in Missouri hiring otr drivers in 2026?
Yes — otr driver demand in Missouri is high heading into 2026. Carriers operating in Missouri are actively recruiting otr drivers with competitive pay packages and benefits to fill open positions. Check individual carrier listings for current openings and application requirements in MO.