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Missouri · MO

Trucking Jobs in St. Louis, MO

CDL driver opportunities, local salary data, top industries, and major employers in St. Louis, Missouri.

Avg CDL Salary

$50,000 - $68,000

Population

2,800,000

Truck Stops

32

Cost of Living

Below Average

Top Industries in St. Louis

These industries drive freight demand and create the most CDL trucking jobs in the St. Louis metropolitan area.

1
Automotive Manufacturing
2
Brewing & Beverage
3
Agricultural Processing
4
Aerospace & Defense
5
Healthcare & Pharmaceuticals

Major Trucking Employers in St. Louis

These companies and facilities employ CDL truck drivers and logistics professionals in the St. Louis, MO area.

Anheuser-Busch InBev
Boeing
Monsanto (Bayer)
General Motors
Stifel Financial

Nearby Interstates & Freight Corridors

These major highways serve St. Louis and carry the highest volumes of commercial truck traffic through the area.

I-70
I-64
I-55
I-44

Trucking in St. Louis, MO

St. Louis's position at the intersection of America's two greatest rivers and three major interstates creates a freight environment few cities can match for diversity. Anheuser-Busch's flagship brewery in the city's south side is the largest brewery in the United States, generating a constant stream of beverage distribution freight handled by both the company's private fleet and contracted carriers. Boeing's defense manufacturing operations in north St. Louis County produce some of the most advanced military aircraft in the world, requiring specialized oversized and high-security freight handling. The Gateway Commerce Center in Madison County, Illinois has become one of the fastest-growing distribution parks in the Midwest, attracting Amazon, World Wide Technology, and Procter & Gamble. St. Louis's extremely affordable cost of living — roughly 15% below the national average — makes it one of the best value propositions for truck drivers who want urban amenities without urban prices.

See all trucking jobs in Missouri

CDL salary data, freight corridors, and industries across MO

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Frequently Asked Questions About Trucking in St. Louis

What role does the Mississippi River play in St. Louis freight?

St. Louis is the second-largest inland river port in the U.S. Barge-to-truck transfers of grain, coal, and bulk materials create steady freight demand. The river port handles over 30 million tons of cargo annually.

What major manufacturers are in St. Louis?

Anheuser-Busch's flagship brewery ships beer nationwide. Boeing builds military aircraft (F-15, F/A-18, T-7A). GM operates an assembly plant in Wentzville. Bayer/Monsanto headquarters drive agricultural product freight.

How does St. Louis compare to Kansas City for trucking?

St. Louis has a more diverse manufacturing base and river port access. Kansas City has a more central location. Both benefit from Missouri's low costs and central geography. Many carriers operate terminals in both cities.