Trucking Jobs in San Diego, CA

San Diego's freight market blends military logistics, biotech cold chain, and cross-border trade in a combination found nowhere else. The Otay Mesa port of entry handles freight from Tijuana's massive maquiladora zone, where 600+ factories produce televisions, medical devices, aerospace components, and consumer electronics for the U.S. market. Naval Base San Diego homeports the Pacific Fleet's surface ships, and provisioning aircraft carriers and destroyers requires extraordinary freight volumes — a single carrier deployment requires thousands of pallets of food, parts, and supplies loaded by truck. The Torrey Pines biotech cluster, home to Illumina, Ionis Pharmaceuticals, and dozens of smaller firms, produces biological materials and medications that demand validated cold chain transport at precise temperatures. General Atomics builds Predator and Reaper drones, generating classified defense freight. San Diego's high cost of living is the primary drawback, though wages reflect the premium, and drivers who base in Temecula or Escondido can reduce housing costs while remaining close to freight.